4ykr: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 4ykr is ON HOLD  until Mar 04 2017
==Heat Shock Protein 90 Bound to CS302==
 
<StructureSection load='4ykr' size='340' side='right' caption='[[4ykr]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
Authors: Kang, Y.N., Stuckey, J.A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ykr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YKR FirstGlance]. <br>
Description: Heat Shock Protein 90 Bound to CS302
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4EP:1-(2,4-DIHYDROXY-5-PROPYLPHENYL)-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE'>4EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ykq|4ykq]], [[4ykt|4ykt]], [[4yku|4yku]], [[4ykw|4ykw]], [[4ykx|4ykx]], [[4yky|4yky]], [[4ykz|4ykz]]</td></tr>
[[Category: Stuckey, J.A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ykr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ykr OCA], [http://pdbe.org/4ykr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ykr RCSB], [http://www.ebi.ac.uk/pdbsum/4ykr PDBsum]</span></td></tr>
[[Category: Kang, Y.N]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Kang, Y N]]
[[Category: Stuckey, J A]]
[[Category: Chaperone]]
[[Category: Chaperone-inhibitor complex]]
[[Category: Hsp 90]]
[[Category: Protein-inhibitor complex]]

Revision as of 06:49, 10 March 2016

Heat Shock Protein 90 Bound to CS302Heat Shock Protein 90 Bound to CS302

Structural highlights

4ykr is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.[1] [2]

References

  1. ↑ Martinez-Ruiz A, Villanueva L, Gonzalez de Orduna C, Lopez-Ferrer D, Higueras MA, Tarin C, Rodriguez-Crespo I, Vazquez J, Lamas S. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8525-30. Epub 2005 Jun 3. PMID:15937123 doi:10.1073/pnas.0407294102
  2. ↑ Forsythe HL, Jarvis JL, Turner JW, Elmore LW, Holt SE. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J Biol Chem. 2001 May 11;276(19):15571-4. Epub 2001 Mar 23. PMID:11274138 doi:10.1074/jbc.C100055200

4ykr, resolution 1.61Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4ykr&oldid=2582136"