Glucocorticoid receptor: Difference between revisions
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{{STRUCTURE_3g6r| PDB=3g6r | SIZE=400| SCENE= |right| CAPTION= Rat glucocorticoid receptor DNA-binding domain dimer complex with DNA and Zn+2 ions (grey), [[3g6r]] }} | {{STRUCTURE_3g6r| PDB=3g6r | SIZE=400| SCENE= |right| CAPTION= Rat glucocorticoid receptor DNA-binding domain dimer complex with DNA and Zn+2 ions (grey), [[3g6r]] }} | ||
== Function == | |||
'''Glucocorticoid receptor''' (GCR) is the nuclear receptor binding cortisol and glucocorticoids. GCR regulates genes involved in development, metabolism and immune response. GCR interacts with nuclear receptor coactivator 2 (NCOA2) which promotes DNA transcription by acylating histones<ref>PMID:17132855</ref>. | |||
== Relevance == | |||
'''Glucocorticoid receptor''' (GCR) is the nuclear receptor binding cortisol and glucocorticoids. GCR regulates genes involved in development, metabolism and immune response. The glucocorticoid-bound GCR can either up-regulate the expression of anti-inflammatory proteins (transactivation) or repress the expression of pro-inflammatory proteins (transrepression). | |||
The glucocorticoid-bound GCR can either up-regulate the expression of anti-inflammatory proteins (transactivation) or repress the expression of pro-inflammatory proteins (transrepression)<ref>PMID:24113652</ref>. | |||
== Structural highlights == | |||
GCR contains 5 domains: N terminal regulatory domain; DNA-binding domain (DBD); hinge region; ligand-binding domain (LBD) and C terminal domain. | |||
==3D structures of glucocorticoid receptor== | ==3D structures of glucocorticoid receptor== | ||
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**[[1p93]] - hGCR LBD+hinge (mutant) + NCOA2 peptide + steroid<br /> | **[[1p93]] - hGCR LBD+hinge (mutant) + NCOA2 peptide + steroid<br /> | ||
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== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||