Geranylgeranyl pyrophosphate synthase: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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{{STRUCTURE_2z4v| PDB=2z4v | SIZE=350| SCENE= |right|CAPTION=Geranylgeranyl pyrophosphate synthase dimer complex with GGPP and Mg+2 (green) [[2z4v]] }} | {{STRUCTURE_2z4v| PDB=2z4v | SIZE=350| SCENE= |right|CAPTION=Geranylgeranyl pyrophosphate synthase dimer complex with GGPP and Mg+2 (green) [[2z4v]] }} | ||
== Function == | |||
'''Geranylgeranyl pyrophosphate synthase''' (GGPPS) catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate and isopentenyl diphosphate. GGPPS is involved in the addition of hydrophobic molecules to proteins and in the regulation of a nuclear hormone receptor. | '''Geranylgeranyl pyrophosphate synthase''' (GGPPS) catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate and isopentenyl diphosphate. GGPPS is involved in the addition of hydrophobic molecules to proteins and in the regulation of a nuclear hormone receptor. | ||
== Relevance == | |||
GGPPS inhibitors are studied as therapeutical targets since geranylgeranylation is a post-translational modification of several proteins involved in human disease<ref>PMID:22048229</ref>. | |||
== 3D Structures of geranylgeranyl pyrophosphate synthase== | == 3D Structures of geranylgeranyl pyrophosphate synthase== | ||
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[[2j1o]] – SaGGPPS – ''Sinapis alba''<br /> | [[2j1o]] – SaGGPPS – ''Sinapis alba''<br /> | ||
[[2j1p]] – SaGGPPS + GGPP<br /> | [[2j1p]] – SaGGPPS + GGPP<br /> | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||