5heg: Difference between revisions

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'''Unreleased structure'''


The entry 5heg is ON HOLD  until Paper Publication
==Pentameric ligand-gated ion channel GLIC mutant P246G==
 
<StructureSection load='5heg' size='340' side='right' caption='[[5heg]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
Authors: Bertozzi, C., Hilf, R.J.C., Dtuzler, R.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5heg]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HEG FirstGlance]. <br>
Description: Pentameric ligand-gated ion channel GLIC mutant P246G
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ehz|3ehz]]</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5heg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5heg OCA], [http://pdbe.org/5heg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5heg RCSB], [http://www.ebi.ac.uk/pdbsum/5heg PDBsum]</span></td></tr>
[[Category: Hilf, R.J.C]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bertozzi, C]]
[[Category: Bertozzi, C]]
[[Category: Dtuzler, R]]
[[Category: Dtuzler, R]]
[[Category: Hilf, R J.C]]
[[Category: Ligand-gated ion channel]]
[[Category: Membrane protein]]
[[Category: Pentameric ligand-gated ion channel]]
[[Category: Transport protein]]

Revision as of 18:29, 2 March 2016

Pentameric ligand-gated ion channel GLIC mutant P246GPentameric ligand-gated ion channel GLIC mutant P246G

Structural highlights

5heg is a 5 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]

References

  1. ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371

5heg, resolution 3.21Å

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