Fumarase: Difference between revisions
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== Function == | == Function == | ||
'''Fumarase''' is used in the citric acid cycle to conduct a transition step in the production of energy to make NADH. It metabolizes | '''Fumarase''' is used in the citric acid cycle to conduct a transition step in the production of energy to make NADH. It metabolizes fumarate in the cytosol, which becomes a byproduct of the urea cycle and amino acid catabolism. It catalyzes the addition of water to make S-malate. This is a reversible reaction. See also:<br /> | ||
*[[Krebs cycle carbons]] | *[[Krebs cycle carbons]] | ||
*[[Krebs cycle importance]] | *[[Krebs cycle importance]] | ||
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'''Fumarase''' or '''fumarate hydratase''' is dominant in fetal and adult tissues and largely expressed in the skin, parathyroid, lymph, and colon | '''Fumarase''' or '''fumarate hydratase''' is dominant in fetal and adult tissues and largely expressed in the skin, parathyroid, lymph, and colon | ||
There are two classes of | There are two classes of fumarases, which depend on the arrangement of their relative subunit, their metal requirement, and their thermal stability. '''Class I fumarases''' can change their state or become inactive when exposed to heat or radiation. They are sensitive to superoxide anions and Fe2+ dependent. '''Class II fumarases''' are found in eukaryotes and prokaryotes. They are iron-independent and thermal-stable. | ||
== Disease == | |||
Fumarase deficiency is an autosomal recessive metabolic disorder distinguished by a deficiency of the enzyme fumarate hydratase and indicated by an excess of fumaric acid in the urine. It is common in infants with neurologic abnormalities and its potential causes include cytosolic and mitochondrial forms of fumarase. | |||
==Fumarase Scenes== | ==Fumarase Scenes== | ||
Revision as of 15:11, 2 March 2016
FunctionFunction
Fumarase is used in the citric acid cycle to conduct a transition step in the production of energy to make NADH. It metabolizes fumarate in the cytosol, which becomes a byproduct of the urea cycle and amino acid catabolism. It catalyzes the addition of water to make S-malate. This is a reversible reaction. See also:
Other interesting informationOther interesting information
Fumarase or fumarate hydratase is dominant in fetal and adult tissues and largely expressed in the skin, parathyroid, lymph, and colon There are two classes of fumarases, which depend on the arrangement of their relative subunit, their metal requirement, and their thermal stability. Class I fumarases can change their state or become inactive when exposed to heat or radiation. They are sensitive to superoxide anions and Fe2+ dependent. Class II fumarases are found in eukaryotes and prokaryotes. They are iron-independent and thermal-stable.
DiseaseDisease
Fumarase deficiency is an autosomal recessive metabolic disorder distinguished by a deficiency of the enzyme fumarate hydratase and indicated by an excess of fumaric acid in the urine. It is common in infants with neurologic abnormalities and its potential causes include cytosolic and mitochondrial forms of fumarase.
Fumarase ScenesFumarase Scenes
3D structures of fumarase3D structures of fumarase
Updated on 02-March-2016
ReferencesReferences
Wikipedia. <http://en.wikipedia.org/wiki/Fumarase>, Wikipedia. <http://en.wikipedia.org/wiki/Enolase>, University of Wisconsin- Eau Claire. <http://www.chem.uwec.edu/Webpapers_F99/Pages/Webpapers_F99/golnercm/Pages/descrip.html>, Virtual Chembook. Elmhurst College. <http://www.elmhurst.edu/~chm/vchembook/601glycolysisrx.html>
AuthorAuthor
Originally Completed by Sydney Park