Tau protein: Difference between revisions
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See also [[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]. | See also [[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]. | ||
'''Alternative Splicing''' | '''Alternative Splicing''' | ||
Alternative splicing of the human tau gene 17q21 generates several isoform structures, which differ by one or two small inserts in its N-terminal region <ref name="Lei">PMID: 20678581</ref>. Although there are 16 exons within the 17q21 gene, exons 4A, 6, and 8 are expressed in peripheral rather than neural tau proteins <ref name="Buee">Buee, L, Bussiere, T, Buee-Scherrer, V, Delacourte, A, Hof, PR. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res. Rev. 33:95-130 (2000). DOI: 10.1016/S0165-0173(00)00019-9</ref>. Alternatively, eight of the exons (1, 4, 5, 7, 9, 11, 12, and 13) are involved in structural aspects of tau <ref name="Buee"/>. Alternative splicing of exons 2, 3, and 10 is responsible for the 6 isoforms of tau <ref name="Lei"/>. These isoforms differ in 3 or 4 tubulin binding domains within the C-terminal region <ref name="Kolarova"/>. | Alternative splicing of the human tau gene 17q21 generates several isoform structures, which differ by one or two small inserts in its N-terminal region <ref name="Lei">PMID: 20678581</ref>. Although there are 16 exons within the 17q21 gene, exons 4A, 6, and 8 are expressed in peripheral rather than neural tau proteins <ref name="Buee">Buee, L, Bussiere, T, Buee-Scherrer, V, Delacourte, A, Hof, PR. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res. Rev. 33:95-130 (2000). DOI: 10.1016/S0165-0173(00)00019-9</ref>. Alternatively, eight of the exons (1, 4, 5, 7, 9, 11, 12, and 13) are involved in structural aspects of tau <ref name="Buee"/>. Alternative splicing of exons 2, 3, and 10 is responsible for the 6 isoforms of tau <ref name="Lei"/>. These isoforms differ in 3 or 4 tubulin binding domains within the C-terminal region <ref name="Kolarova"/>. | ||