Ficolin: Difference between revisions

Revision as of 14:17, 21 February 2016

Function

Ficolin (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules^[1]. 3 ficolins were identified in humans L-Fic or ficolin-2, H-Fic or ficolin-3 and M-Fic or ficolin-1.

Disease

Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy^[2].

Structural highlights

.

(PDB code 2j64).^[3] Water molecules shown as red spheres.

Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code 2j64)

Drag the structure with the mouse to rotate

3D Structures of Ficolin3D Structures of Ficolin

Updated on 21-February-2016

ReferencesReferences

↑ Lu J, Le Y. Ficolins and the fibrinogen-like domain. Immunobiology. 1998 Aug;199(2):190-9. PMID:9777405 doi:http://dx.doi.org/10.1016/S0171-2985(98)80026-0
↑ Zhang XL, Ali MA. Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 2008;632:105-15. PMID:19025118
↑ Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C. Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J. 2007 Jan 24;26(2):623-33. Epub 2007 Jan 11. PMID:17215869

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Lu J, Le Y. Ficolins and the fibrinogen-like domain. Immunobiology. 1998 Aug;199(2):190-9. PMID:9777405 doi:http://dx.doi.org/10.1016/S0171-2985(98)80026-0

[2] Zhang XL, Ali MA. Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 2008;632:105-15. PMID:19025118

[3] Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C. Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J. 2007 Jan 24;26(2):623-33. Epub 2007 Jan 11. PMID:17215869

[1]

[2]

[3]

@@ Line 13: / Line 13: @@
 <scene name='46/466464/Cv/2'>Human H-ficolin binding domain trimer</scene>.
-<scene name='46/466464/Cv/3'>Ca coordination site</scene> (PDB code [[2j64]]).<ref>PMID:17215869</ref>
+<scene name='46/466464/Cv/3'>Ca coordination site</scene> (PDB code [[2j64]]).<ref>PMID:17215869</ref> Water molecules shown as red spheres.
 </StructureSection>
 == 3D Structures of Ficolin ==