4ye6: Difference between revisions

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'''Unreleased structure'''


The entry 4ye6 is ON HOLD  until Paper Publication
==The crystal structure of the intact human GlnRS==
 
<StructureSection load='4ye6' size='340' side='right' caption='[[4ye6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Ognjenovic, J., Wu, J., Ling, J., Simonovic, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ye6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YE6 FirstGlance]. <br>
Description: The crystal structure of the intact human GlnRS
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ye8|4ye8]], [[4ye9|4ye9]]</td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ye6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ye6 OCA], [http://pdbe.org/4ye6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ye6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ye6 PDBsum]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN]] Plays a critical role in brain development.<ref>PMID:24656866</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Glutamine--tRNA ligase]]
[[Category: Ling, J]]
[[Category: Ling, J]]
[[Category: Ognjenovic, J]]
[[Category: Ognjenovic, J]]
[[Category: Simonovic, M]]
[[Category: Wu, J]]
[[Category: Wu, J]]
[[Category: Simonovic, M]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Class i aar]]
[[Category: L-glutamine]]
[[Category: Ligase]]

Revision as of 05:50, 21 February 2016

The crystal structure of the intact human GlnRSThe crystal structure of the intact human GlnRS

Structural highlights

4ye6 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:Glutamine--tRNA ligase, with EC number 6.1.1.18
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Disease

[SYQ_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.

Function

[SYQ_HUMAN] Plays a critical role in brain development.[1]

References

  1. ↑ Zhang X, Ling J, Barcia G, Jing L, Wu J, Barry BJ, Mochida GH, Hill RS, Weimer JM, Stein Q, Poduri A, Partlow JN, Ville D, Dulac O, Yu TW, Lam AT, Servattalab S, Rodriguez J, Boddaert N, Munnich A, Colleaux L, Zon LI, Soll D, Walsh CA, Nabbout R. Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014 Apr 3;94(4):547-58. doi: 10.1016/j.ajhg.2014.03.003. Epub, 2014 Mar 20. PMID:24656866 doi:http://dx.doi.org/10.1016/j.ajhg.2014.03.003

4ye6, resolution 2.40Å

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OCA
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