4xem: Difference between revisions

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-'''Unreleased structure'''
-The entry 4xem is ON HOLD  until Paper Publication
+==Crystal Structure of wild type human AlaRS catalytic domain==
+<StructureSection load='4xem' size='340' side='right' caption='[[4xem]], [[Resolution|resolution]] 1.28&Aring;' scene=''>
-Authors: Zhou, H., He, W., Yang, X.L.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4xem]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XEM FirstGlance]. <br>
-Description: Crystal Structure of wild type human AlaRS catalytic domain
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A5A:5-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE'>A5A</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine--tRNA_ligase Alanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.7 6.1.1.7] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xem OCA], [http://pdbe.org/4xem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xem RCSB], [http://www.ebi.ac.uk/pdbsum/4xem PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/SYAC_HUMAN SYAC_HUMAN]] Autosomal dominant Charcot-Marie-Tooth disease type 2N. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/SYAC_HUMAN SYAC_HUMAN]] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133]
+__TOC__
+</StructureSection>
+[[Category: Alanine--tRNA ligase]]
+[[Category: He, W]]
+[[Category: Yang, X L]]
 [[Category: Zhou, H]]
-[[Category: Yang, X.L]]
+[[Category: Ligase]]
-[[Category: He, W]]
+[[Category: Trna synthetase]]