Exportin: Difference between revisions

Revision as of 13:22, 15 February 2016

Exportins (XPO) or chromosomal maintenance protein mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. XPO-t exports tRNA from the nucleus^[1].

Structural highlights

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(PDB code 3icq).^[2]

Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code 3icq).

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3D structures of exportin3D structures of exportin

Updated on 15-February-2016

ReferencesReferences

↑ Kohler A, Hurt E. Exporting RNA from the nucleus to the cytoplasm. Nat Rev Mol Cell Biol. 2007 Oct;8(10):761-73. PMID:17786152 doi:http://dx.doi.org/10.1038/nrm2255
↑ Cook AG, Fukuhara N, Jinek M, Conti E. Structures of the tRNA export factor in the nuclear and cytosolic states. Nature. 2009 Sep 3;461(7260):60-5. PMID:19680239 doi:10.1038/nature08394

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Kohler A, Hurt E. Exporting RNA from the nucleus to the cytoplasm. Nat Rev Mol Cell Biol. 2007 Oct;8(10):761-73. PMID:17786152 doi:http://dx.doi.org/10.1038/nrm2255

[2] Cook AG, Fukuhara N, Jinek M, Conti E. Structures of the tRNA export factor in the nuclear and cytosolic states. Nature. 2009 Sep 3;461(7260):60-5. PMID:19680239 doi:10.1038/nature08394

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@@ Line 3: / Line 3: @@
 '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA.  XPO is regulated by GTPaseRan.  RanGTP bind to XPO forming a ternary complex with the exported protein.  The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates.  '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.
-==Structural highlighta ==
+==Structural highlights ==
-<scene name='59/592125/Cv/2'>Yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene> (PDB code [[3icq]]).
+<scene name='59/592125/Cv/2'>Yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene>.
-<scene name='59/592125/Cv/6'>GTP binding site</scene>
+<scene name='59/592125/Cv/6'>GTP binding site</scene>.
+<scene name='59/592125/Cv/7'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref>
 </StructureSection>