Exoenzyme

Exoenzymes (Exo) are secreted by cells and break large macromolecules outside the cells. The breakdown components can pass through the cell wall. Exo C3 is a Clostridium butulinum toxin which binds NAD, splits it into ADP-ribose and nicotinamide and transfers the ADP-ribose to a protein substrate. Exo S and Exo T are secreted by Pseudomonas aeruginosa and has GTPase-activating activity as well as ADP-ribosyltransferase activity .

spinqualitylabelsall models Structure of exoenzyme C3 catalytic domain complex with ADP and NAD (PDB code 2c8c). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of exoenzyme3D structures of exoenzyme

Updated on 14-February-2016

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• Exoenzyme C3
  • 1g24 – CbExo residues 8-218 – Clostridium butulinum
    
  • 1uzi, 1r45, 1r4b, 2c89 – CbExo catalytic domain
    
  • 1gze, 2c8b, 2c8d, 2c8e, 2c8g – CbExo catalytic domain (mutant)
    
  • 3bw8 - Exo catalytic domain - Clostridium limosum
    
• Exoenzyme C3 complexes
  • 1gzf – CbExo catalytic domain + pyridinium derivative + ADP + NAD
    
  • 2bov – CbExo + GDP + Ral-A GTPase
    
  • 2a78 – CbExo catalytic domain + GDP + Ral-A GTPase
    
  • 2a9k – CbExo catalytic domain+ GDP + Ral-A GTPase + NAD
    
  • 2c8a – CbExo catalytic domain + nicotinamide
    
  • 2c8c – CbExo catalytic domain (mutant) + ADP + NAD
    
  • 2c8f, 2c8h – CbExo catalytic domain (mutant) + NAD
    
• Exoenzyme S
  • 1r4t – PaExo GAP domain – Pseudomonas aeruginosa - NMR
    
  • 1he1 – PaExo GAP domain + Ras-like protein + GDP
    
  • 1he9 – PaExo GAP domain + Ras-like protein
    
• Exoenzyme T
  • 4jmf – PaExo residues 28-77 + chaperone