Bromodomain-containing protein: Difference between revisions
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'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones. | '''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones. | ||
<ref>PMID:21638687</ref> | <ref>PMID:21638687</ref> | ||
For detalis on BRD3 see [[Human bromodomain containing protein 3]] | For detalis on BRD3 see [[Human bromodomain containing protein 3]] | ||
== Disease == | == Disease == | ||
Dysfunction of BRD is involved in cancer, inflammation and multiple sclerosis. | Dysfunction of BRD is involved in cancer, inflammation, obesity and multiple sclerosis<ref>PMID:22722403</ref>. | ||
== Relevance == | == Relevance == | ||