1n4y

REFINED STRUCTURE OF KISTRINREFINED STRUCTURE OF KISTRIN

Structural highlights 1n4y is a 1 chain structure with sequence from Agkistrodon rhodostoma. This structure supersedes the now removed PDB entry 1kst. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 1kst Gene: RHOD (Agkistrodon rhodostoma) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein. Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.,Adler M, Lazarus RA, Dennis MS, Wagner G Science. 1991 Jul 26;253(5018):445-8. PMID:1862345 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Disintegrin

spinqualitylabelsall models 1n4y, 18 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image