Ephrin: Difference between revisions
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<StructureSection load='3mx0' size='340' side='right' caption='Structure of glycosylated human ephrin-A5 receptor-binding domain | <StructureSection load='3mx0' size='340' side='right' caption='Structure of glycosylated human ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2 (PDB code [[3mx0]]).' scene='59/594659/Cv/1'> | ||
== Function == | == Function == | ||
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== Disease == | == Disease == | ||
Eph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury. | Eph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury. | ||
== Structural highlights == | |||
<scene name='59/594659/Cv/2'>Ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2</scene> (PDB code [[3mx0]]).<ref>PMID:20505120</ref> | |||
</StructureSection> | </StructureSection> | ||
Revision as of 16:26, 9 February 2016
FunctionEphrins (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation [1]. DiseaseEph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury. Structural highlights |
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3D structures of ephrin3D structures of ephrin
Updated on 09-February-2016
ReferencesReferences
- ↑ Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007 May;17(5):230-8. Epub 2007 Apr 8. PMID:17420126 doi:http://dx.doi.org/10.1016/j.tcb.2007.03.004
- ↑ Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A. 2010 May 26. PMID:20505120