1efd: Difference between revisions

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|ACTIVITY=  
|ACTIVITY=  
|GENE=  
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|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1efd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1efd OCA], [http://www.ebi.ac.uk/pdbsum/1efd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1efd RCSB]</span>
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[[Category: Tari, L W.]]
[[Category: Tari, L W.]]
[[Category: Vogel, H J.]]
[[Category: Vogel, H J.]]
[[Category: GCR]]
[[Category: escherichia coli]]
[[Category: escherichia coli]]
[[Category: ferric siderophore binding protein]]
[[Category: ferric siderophore binding protein]]
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[[Category: periplasmic binding protein-siderophore complex]]
[[Category: periplasmic binding protein-siderophore complex]]


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Revision as of 20:01, 30 March 2008

File:1efd.gif


PDB ID 1efd

Drag the structure with the mouse to rotate
, resolution 1.9Å
Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME


OverviewOverview

Siderophore binding proteins play a key role in the uptake of iron in many gram-positive and gram-negative bacteria. FhuD is a soluble periplasmic binding protein that transports ferrichrome and other hydroxamate siderophores. The crystal structure of FhuD from Escherichia coli in complex with the ferrichrome homolog gallichrome has been determined at 1.9 inverted question mark resolution, the first structure of a periplasmic binding protein involved in the uptake of siderophores. Gallichrome is held in a shallow pocket lined with aromatic groups; Arg and Tyr side chains interact directly with the hydroxamate moieties of the siderophore. FhuD possesses a novel fold, suggesting that its mechanisms of ligand binding and release are different from other structurally characterized periplasmic ligand binding proteins.

About this StructureAbout this Structure

1EFD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the ferric siderophore binding protein FhuD complexed with gallichrome., Clarke TE, Ku SY, Dougan DR, Vogel HJ, Tari LW, Nat Struct Biol. 2000 Apr;7(4):287-91. PMID:10742172

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