1e7f: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
|PDB= 1e7f |SIZE=350|CAPTION= <scene name='initialview01'>1e7f</scene>, resolution 2.43Å | |PDB= 1e7f |SIZE=350|CAPTION= <scene name='initialview01'>1e7f</scene>, resolution 2.43Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=DAO:LAURIC ACID'>DAO</scene> | |LIGAND= <scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= ALB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= ALB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e7f OCA], [http://www.ebi.ac.uk/pdbsum/1e7f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e7f RCSB]</span> | |||
}} | }} | ||
| Line 16: | Line 19: | ||
==Disease== | ==Disease== | ||
Known | Known disease associated with this structure: Analbuminemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]], Dysalbuminemic hyperthyroxinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]], Dysalbuminemic hyperzincemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]] | ||
==About this Structure== | ==About this Structure== | ||
| Line 28: | Line 31: | ||
[[Category: Curry, S.]] | [[Category: Curry, S.]] | ||
[[Category: Gruene, T.]] | [[Category: Gruene, T.]] | ||
[[Category: lipid-binding]] | [[Category: lipid-binding]] | ||
[[Category: metal-binding]] | [[Category: metal-binding]] | ||
[[Category: plasma protein]] | [[Category: plasma protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:56:48 2008'' | ||
Revision as of 19:56, 30 March 2008
| |||||||
| , resolution 2.43Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | ALB (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN SERUM ALBUMIN COMPLEXED WITH DODECANOIC ACID (LAURIC ACID)
OverviewOverview
Human serum albumin (HSA) is an abundant plasma protein that is responsible for the transport of fatty acids. HSA also binds and perturbs the pharmacokinetics of a wide range of drug compounds. Binding studies have revealed significant interactions between fatty acid and drug-binding sites on albumin but high-resolution structural information on ligand binding to the protein has been lacking. We report here a crystallographic study of five HSA-fatty acid complexes formed using saturated medium-chain and long-chain fatty acids (C10:0, C12:0, C14:0, C16:0 and C18:0). A total of seven binding sites that are occupied by all medium-chain and long-chain fatty acids have been identified, although medium-chain fatty acids are found to bind at additional sites on the protein, yielding a total of 11 distinct binding locations. Comparison of the different complexes reveals key similarities and significant differences in the modes of binding, and serves to rationalise much of the biochemical data on fatty acid interactions with albumin. The two principal drug-binding sites, in sub-domains IIA and IIIA, are observed to be occupied by fatty acids and one of them (in IIIA) appears to coincide with a high-affinity long-chain fatty acid binding site.
DiseaseDisease
Known disease associated with this structure: Analbuminemia OMIM:[103600], Dysalbuminemic hyperthyroxinemia OMIM:[103600], Dysalbuminemic hyperzincemia OMIM:[103600]
About this StructureAbout this Structure
1E7F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin., Bhattacharya AA, Grune T, Curry S, J Mol Biol. 2000 Nov 10;303(5):721-32. PMID:11061971
Page seeded by OCA on Sun Mar 30 19:56:48 2008