1dzl: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzl OCA], [http://www.ebi.ac.uk/pdbsum/1dzl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dzl RCSB]</span> | |||
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==About this Structure== | ==About this Structure== | ||
1DZL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | 1DZL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZL OCA]. | ||
==Reference== | ==Reference== | ||
Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16., Chen XS, Garcea RL, Goldberg I, Casini G, Harrison SC, Mol Cell. 2000 Mar;5(3):557-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10882140 10882140] | Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16., Chen XS, Garcea RL, Goldberg I, Casini G, Harrison SC, Mol Cell. 2000 Mar;5(3):557-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10882140 10882140] | ||
[[Category: Human papillomavirus type | [[Category: Human papillomavirus type 16]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Chen, X J.]] | [[Category: Chen, X J.]] | ||
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[[Category: icosahedral]] | [[Category: icosahedral]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:51:58 2008'' | ||
Revision as of 19:51, 30 March 2008
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| , resolution 3.50Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16
OverviewOverview
The papillomavirus major late protein, L1, forms the pentameric assembly unit of the viral shell. Recombinant HPV16 L1 pentamers assemble in vitro into capsid-like structures, and truncation of ten N-terminal residues leads to a homogeneous preparation of 12-pentamer, icosahedral particles. X-ray crystallographic analysis of these particles at 3.5 A resolution shows that L1 closely resembles VP1 from polyomaviruses. Surface loops contain the sites of sequence variation among HPV types and the locations of dominant neutralizing epitopes. The ease with which small virus-like particles may be obtained from L1 expressed in E. coli makes them attractive candidate components of a papillomavirus vaccine. Their crystal structure also provides a starting point for future vaccine design.
About this StructureAbout this Structure
1DZL is a Single protein structure of sequence from Human papillomavirus type 16. Full crystallographic information is available from OCA.
ReferenceReference
Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16., Chen XS, Garcea RL, Goldberg I, Casini G, Harrison SC, Mol Cell. 2000 Mar;5(3):557-67. PMID:10882140
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