2vwf: Difference between revisions
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<StructureSection load='2vwf' size='340' side='right' caption='[[2vwf]], [[Resolution|resolution]] 1.58Å' scene=''> | <StructureSection load='2vwf' size='340' side='right' caption='[[2vwf]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vwf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2vwf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VWF FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2h46|2h46]], [[1qg1|1qg1]], [[1cj1|1cj1]], [[1bm2|1bm2]], [[1gfd|1gfd]], [[1fyr|1fyr]], [[1jyu|1jyu]], [[1bmb|1bmb]], [[1jyq|1jyq]], [[1gfc|1gfc]], [[2aob|2aob]], [[1x0n|1x0n]], [[1tze|1tze]], [[1aze|1aze]], [[1gri|1gri]], [[2vvk|2vvk]], [[1io6|1io6]], [[1fhs|1fhs]], [[1zfp|1zfp]], [[1gcq|1gcq]], [[1ghu|1ghu]], [[2aoa|2aoa]], [[1jyr|1jyr]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2h46|2h46]], [[1qg1|1qg1]], [[1cj1|1cj1]], [[1bm2|1bm2]], [[1gfd|1gfd]], [[1fyr|1fyr]], [[1jyu|1jyu]], [[1bmb|1bmb]], [[1jyq|1jyq]], [[1gfc|1gfc]], [[2aob|2aob]], [[1x0n|1x0n]], [[1tze|1tze]], [[1aze|1aze]], [[1gri|1gri]], [[2vvk|2vvk]], [[1io6|1io6]], [[1fhs|1fhs]], [[1zfp|1zfp]], [[1gcq|1gcq]], [[1ghu|1ghu]], [[2aoa|2aoa]], [[1jyr|1jyr]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vwf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vwf RCSB], [http://www.ebi.ac.uk/pdbsum/2vwf PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vwf OCA], [http://pdbe.org/2vwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vwf RCSB], [http://www.ebi.ac.uk/pdbsum/2vwf PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vwf ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2vwf" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Feller, S M]] | [[Category: Feller, S M]] | ||
[[Category: Harkiolaki, M]] | [[Category: Harkiolaki, M]] | ||
Revision as of 08:50, 8 February 2016
GRB2 SH3C (2)GRB2 SH3C (2)
Structural highlights
Function[GAB2_HUMAN] Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.[1] [2] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedGrb2 and Gab2 form a complex implicated in normal cell signaling and cancer development. Binding of the Grb2SH3C domain to Gab2 is essential for the interaction, but molecular details remained undefined. Using peptide arrays and isothermal titration calorimetry, two Grb2SH3C binding sites in Gab2 (Gab2a and Gab2b) were confirmed and characterized. Gab2a bears similarity to a p27Kip1 epitope that also binds Grb2SH3C. Crystal structures of both Gab2 epitopes complexed with Grb2SH3C reveal that Gab2b contains a 3(10) helix that positions the arginine and lysine of the core-binding motif RxxK in parallel orientation. In contrast, the Gab2a RxxK motif is embedded in a PPII helix with Arg and Lys in staggered orientation. A similar interaction mode is also present in a new complex of Mona/GadsSH3C with an RxxxxK epitope from the putative phosphatase HD-PTP. In summary, our study reveals interaction types of SH3 domains, highlighting their great versatility. Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.,Harkiolaki M, Tsirka T, Lewitzky M, Simister PC, Joshi D, Bird LE, Jones EY, O'Reilly N, Feller SM Structure. 2009 Jun 10;17(6):809-22. PMID:19523899[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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