7nn9: Difference between revisions

<table><tr><td colspan='2'>[[7nn9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2nn9 2nn9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7NN9 FirstGlance]. <br>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7nn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=7nn9 RCSB], [http://www.ebi.ac.uk/pdbsum/7nn9 PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/NRAM_IATRA NRAM_IATRA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.  

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

[[Category: Viruses]]