1d3u: Difference between revisions
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|PDB= 1d3u |SIZE=350|CAPTION= <scene name='initialview01'>1d3u</scene>, resolution 2.4Å | |PDB= 1d3u |SIZE=350|CAPTION= <scene name='initialview01'>1d3u</scene>, resolution 2.4Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d3u OCA], [http://www.ebi.ac.uk/pdbsum/1d3u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d3u RCSB]</span> | |||
}} | }} | ||
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[[Category: transcription]] | [[Category: transcription]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:34:04 2008'' | ||
Revision as of 19:34, 30 March 2008
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| , resolution 2.4Å | |||||||
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| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI
OverviewOverview
Recently the definition of the metazoan RNA polymerase II and archaeal core promoters has been expanded to include a region immediately upstream of the TATA box called the B recognition element (BRE), so named because eukaryal transcription factor TFIIB and its archaeal orthologue TFB interact with the element in a sequence-specific manner. Here we present the 2.4-A crystal structure of archaeal TBP and the C-terminal core of TFB (TFB(c)) in a complex with an extended TATA-box-containing promoter that provides a detailed picture of the stereospecific interactions between the BRE and a helix-turn-helix motif in the C-terminal cyclin repeat of TFB(c). This interaction is important in determining the level of basal transcription and explicitly defines the direction of transcription.
About this StructureAbout this Structure
1D3U is a Protein complex structure of sequences from Pyrococcus woesei. Full crystallographic information is available from OCA.
ReferenceReference
The structural basis for the oriented assembly of a TBP/TFB/promoter complex., Littlefield O, Korkhin Y, Sigler PB, Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13668-73. PMID:10570130
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