1cx0: Difference between revisions
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|PDB= 1cx0 |SIZE=350|CAPTION= <scene name='initialview01'>1cx0</scene>, resolution 2.30Å | |PDB= 1cx0 |SIZE=350|CAPTION= <scene name='initialview01'>1cx0</scene>, resolution 2.30Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1drz|1DRZ]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cx0 OCA], [http://www.ebi.ac.uk/pdbsum/1cx0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cx0 RCSB]</span> | |||
}} | }} | ||
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[[Category: Doudna, J A.]] | [[Category: Doudna, J A.]] | ||
[[Category: Zhou, K.]] | [[Category: Zhou, K.]] | ||
[[Category: nested double pseudoknot rna structure]] | [[Category: nested double pseudoknot rna structure]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:30:17 2008'' | ||
Revision as of 19:30, 30 March 2008
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| , resolution 2.30Å | |||||||
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| Ligands: | , , , , , | ||||||
| Related: | 1DRZ
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HEPATITIS DELTA VIRUS RIBOZYME
OverviewOverview
The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known to be required for the viability of a human pathogen. We obtained crystals of a 72-nucleotide, self-cleaved form of the genomic HDV ribozyme that diffract X-rays to 2.3 A resolution by engineering the RNA to bind a small, basic protein without affecting ribozyme activity. The co-crystal structure shows that the compact catalytic core comprises five helical segments connected as an intricate nested double pseudoknot. The 5'-hydroxyl leaving group resulting from the self-scission reaction is buried deep within an active-site cleft produced by juxtaposition of the helices and five strand-crossovers, and is surrounded by biochemically important backbone and base functional groups in a manner reminiscent of protein enzymes.
About this StructureAbout this Structure
1CX0 is a Single protein structure of sequence from Hepatitis delta virus. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of a hepatitis delta virus ribozyme., Ferre-D'Amare AR, Zhou K, Doudna JA, Nature. 1998 Oct 8;395(6702):567-74. PMID:9783582
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