1c9h: Difference between revisions
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|PDB= 1c9h |SIZE=350|CAPTION= <scene name='initialview01'>1c9h</scene>, resolution 2.00Å | |PDB= 1c9h |SIZE=350|CAPTION= <scene name='initialview01'>1c9h</scene>, resolution 2.00Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=RAP:RAPAMYCIN IMMUNOSUPPRESSANT DRUG'>RAP</scene> | |LIGAND= <scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1fkl|1FKL]], [[1fap|1FAP]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c9h OCA], [http://www.ebi.ac.uk/pdbsum/1c9h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c9h RCSB]</span> | |||
}} | }} | ||
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[[Category: Narayana, S V.L.]] | [[Category: Narayana, S V.L.]] | ||
[[Category: Thotakura, A.]] | [[Category: Thotakura, A.]] | ||
[[Category: complex]] | [[Category: complex]] | ||
[[Category: fkbp12]] | [[Category: fkbp12]] | ||
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[[Category: ryanodine receptor]] | [[Category: ryanodine receptor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:17:18 2008'' | ||
Revision as of 19:17, 30 March 2008
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| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | CDNA (Homo sapiens) | ||||||
| Related: | 1FKL, 1FAP
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN
OverviewOverview
FKBP12.6 is a novel isoform of FKBP12, which selectively binds to the cardiac ryanodine receptor (RyR2). The crystal structure of FKBP12.6 in complex with rapamycin has now been determined at 2.0 A resolution. The structures of FKBP12.6 and FKBP12 are nearly identical, except for a displacement observed in the helical region of FKBP12.6 toward the hydrophobic pocket. This displacement was not predicted by homology modeling studies. Analyses of the residues that are likely to confer the RyR2-binding specificity are presented.
About this StructureAbout this Structure
1C9H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure of FKBP12.6 in complex with rapamycin., Deivanayagam CC, Carson M, Thotakura A, Narayana SV, Chodavarapu RS, Acta Crystallogr D Biol Crystallogr. 2000 Mar;56(Pt 3):266-71. PMID:10713512
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