2n06: Difference between revisions

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'''Unreleased structure'''
==Mdmx-298==
 
<StructureSection load='2n06' size='340' side='right' caption='[[2n06]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
The entry 2n06 is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2n06]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N06 FirstGlance]. <br>
Authors: Grace, C.R., Kriwacki, R.W.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44Z:4-[[(4S,5R)-5-(4-CHLOROPHENYL)-4-(3-METHOXYPHENYL)-2-(4-METHOXY-2-PROPAN-2-YLOXY-PHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]CARBONYL]PIPERAZIN-2-ONE'>44Z</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mwy|2mwy]], [[2n0u|2n0u]], [[2n0w|2n0w]], [[2n14|2n14]]</td></tr>
Description: Mdmx-298
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n06 OCA], [http://pdbe.org/2n06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n06 RCSB], [http://www.ebi.ac.uk/pdbsum/2n06 PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Kriwacki, R.W]]
== Function ==
[[Category: Grace, C.R]]
[[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Grace, C R]]
[[Category: Kriwacki, R W]]
[[Category: Mdmx]]
[[Category: P53]]
[[Category: Signaling protein]]

Revision as of 05:24, 28 January 2016

Mdmx-298Mdmx-298

Structural highlights

2n06 is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.[1] [2]

References

  1. ↑ Chen L, Gilkes DM, Pan Y, Lane WS, Chen J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 2005 Oct 5;24(19):3411-22. Epub 2005 Sep 15. PMID:16163388 doi:10.1038/sj.emboj.7600812
  2. ↑ Jin Y, Dai MS, Lu SZ, Xu Y, Luo Z, Zhao Y, Lu H. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006 Mar 22;25(6):1207-18. Epub 2006 Mar 2. PMID:16511572 doi:10.1038/sj.emboj.7601010
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