1bx2: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bx2 OCA], [http://www.ebi.ac.uk/pdbsum/1bx2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bx2 RCSB]</span> | |||
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[[Category: Wiley, D C.]] | [[Category: Wiley, D C.]] | ||
[[Category: Wucherpfennig, K.]] | [[Category: Wucherpfennig, K.]] | ||
[[Category: autoimmunity]] | [[Category: autoimmunity]] | ||
[[Category: hla-dr2]] | [[Category: hla-dr2]] | ||
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[[Category: myelin basic protein]] | [[Category: myelin basic protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:10:05 2008'' | ||
Revision as of 19:10, 30 March 2008
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| , resolution 2.6Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN
OverviewOverview
Susceptibility to multiple sclerosis is associated with the human histocompatibility leukocyte antigen (HLA)-DR2 (DRB1*1501) haplotype. The structure of HLA-DR2 was determined with a bound peptide from human myelin basic protein (MBP) that is immunodominant for human MBP-specific T cells. Residues of MBP peptide that are important for T cell receptor recognition are prominent, solvent exposed residues in the crystal structure. A distinguishing feature of the HLA-DR2 peptide binding site is a large, primarily hydrophobic P4 pocket that accommodates a phenylalanine of the MBP peptide. The necessary space for this aromatic side chain is created by an alanine at the polymorphic DRbeta 71 position. These features make the P4 pocket of HLA-DR2 distinct from DR molecules associated with other autoimmune diseases.
About this StructureAbout this Structure
1BX2 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein., Smith KJ, Pyrdol J, Gauthier L, Wiley DC, Wucherpfennig KW, J Exp Med. 1998 Oct 19;188(8):1511-20. PMID:9782128
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