Monocyte chemoattractant protein: Difference between revisions
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== Function == | == Function == | ||
'''Human synthetic monocyte chemoattractant protein 1 (MCP)''' belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The gene for CCL2 is on chromosome 17 in region 17q11.2-q12. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines. The CCL2<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand | '''Human synthetic monocyte chemoattractant protein 1 (MCP)''' belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The gene for CCL2 is on chromosome 17 in region 17q11.2-q12. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines. The CCL2<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand''' or: | ||
- MCP1 | - MCP1 | ||
- small inducible cytokine A2 (SCYA2) | - small inducible cytokine A2 (SCYA2) | ||
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== Disease == | == Disease == | ||
CCL2 is implicated in several diseases like psoriasis, rheumatoid arthritis and | CCL2 is implicated in several diseases like psoriasis, atherosclerosis and rheumatoid arthritis where the appear to recruit macrophages, therefore bolstering the inflammation on joints. | ||
CCL2 has also been found elevated in the urine of people with lupus as a sign warning of inflammation of the kidney. | |||
CCL2 is overexpressed in epilepsy, brain ischemia, Alzheimer's disease, EAE and traumatic brain injury. | |||
== Relevance == | |||
== Structural highlights == | == Structural highlights == | ||