Monocyte chemoattractant protein: Difference between revisions

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 == Function ==
-'''Monocyte chemoattractant protein''' (MCP) belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines.  The MCP-1<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand''' or '''CCL2''' or:
+'''Human synthetic monocyte chemoattractant protein 1 (3IFD)''' (MCP) belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The gene for MCP1 is on chromosome 17 in region 17q11.2-q12. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines.  The MCP-1<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand''' or '''CCL2''' or:
 - small inducible cytokine A2 (SCYA2)
 - MCAF
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 CCL2 is implicated in several diseases like psoriasis, rheumatoid arthritis and atherosclerosis.
+MPC1 is implicated in rheumatoid arthritis where they may serve to recruit macrophages and perpetuate the inflammation in the joints. MPC1 has also been found elevated in the urine of people with lupus as a sign warning of inflammation of the kidney.
 == Relevance ==