Monocyte chemoattractant protein: Difference between revisions
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Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. | |||
== Ligands == | |||
K and PO4 | |||
== Disease == | == Disease == | ||
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CCL2 is part of the C-C motif group because of the covalent bond made between <scene name='72/721520/Cv/4'>2 of the 4 cysteines of the N terminal domain</scene>.<ref>PMID:8989326</ref> | CCL2 is part of the C-C motif group because of the covalent bond made between <scene name='72/721520/Cv/4'>2 of the 4 cysteines of the N terminal domain</scene>.<ref>PMID:8989326</ref> | ||
Post translational modifications at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. | |||
</StructureSection> | </StructureSection> | ||
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http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK | http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK | ||
http://www.uniprot.org/uniprot/P13500#interaction | http://www.uniprot.org/uniprot/P13500#interaction | ||
http://www.rcsb.org/pdb/explore/explore.do?structureId=3IFD | |||
<references/> | <references/> | ||
Revision as of 15:31, 26 January 2016
FunctionMonocyte chemoattractant protein (MCP) belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines. The MCP-1[1] is also known as chemokine (C-C motif) ligand or CCL2 or: - small inducible cytokine A2 (SCYA2) - MCAF - GDCF-2 - SMC-CF - HSMCR30 - MGC9434 - GDCF-2 - HC11. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. LigandsK and PO4 DiseaseCCL2 is implicated in several diseases like psoriasis, rheumatoid arthritis and atherosclerosis. RelevanceCCL2 is overexpressed in epilepsy, brain ischemia, Alzheimer's disease, EAE and traumatic brain injury. Structural highlightsCCL2 is part of the C-C motif group because of the covalent bond made between .[2] Post translational modifications at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. |
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3D structures of Monocyte chemoattractant protein3D structures of Monocyte chemoattractant protein
Updated on 26-January-2016
ReferencesReferences
https://fr.wikipedia.org/wiki/CCL2 http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK http://www.uniprot.org/uniprot/P13500#interaction http://www.rcsb.org/pdb/explore/explore.do?structureId=3IFD
- ↑ Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6. PMID:8170963
- ↑ Lubkowski J, Bujacz G, Boque L, Domaille PJ, Handel TM, Wlodawer A. The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions. Nat Struct Biol. 1997 Jan;4(1):64-9. PMID:8989326