Fibroblast growth factor receptor: Difference between revisions

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Michal Harel, Alexander Berchansky

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-{{STRUCTURE_1evt|  PDB=1evt  | SIZE=400| SCENE= |right|CAPTION= Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 (pink and yellow) complex with fibroblast growth factor 1 (grey and green) and sulfate, [[1evt]] }}
-'''Fibroblast growth factor receptors''' (FGFR) are receptors which bind fibroblast growth factors (FGF).  FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3.  Each FGFR can activate several FGFs.  Five FGFRs have been identified so far.  FGFRs differ in their ligand specificity and tissue distribution.  The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation.
+<StructureSection load='1evt' size='350' side='right' scene='' caption='Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 (pink and yellow) complex with fibroblast growth factor 1 (grey and green) and sulfate (PDB code [[1evt]]) '>
+== Function ==
+'''Fibroblast growth factor receptors''' (FGFR) are receptors which bind fibroblast growth factors (FGF).    Each FGFR can activate several FGFs.  Five FGFRs have been identified so far.  FGFRs differ in their ligand specificity and tissue distribution.  The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation<ref>PMID:8747466</ref>.
+== Structural insights ==
+FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3.
+</StructureSection>
 ==3D structures of fibroblast growth factor receptor==