Ferritin: Difference between revisions
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<applet load='Pdb2jd7.pdb' size='400' frame='true' align='right' scene="Ferritin/Starting_ferritin_scene/1" caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'', [[2jd7]]" /> | <applet load='Pdb2jd7.pdb' size='400' frame='true' align='right' scene="Ferritin/Starting_ferritin_scene/1" caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'', [[2jd7]]" /> | ||
== Function == | |||
[[Ferritin]] (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) | [[Ferritin]] (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) a<ref>PMID:20304033</ref> | ||
nd light chain (FTL). Amphibians have an additional middle subunit FR (FTM).<br /> | |||
* '''Bacterioferritin''' (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity.<br /> | * '''Bacterioferritin''' (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity.<br /> | ||
* '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br /> | * '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br /> | ||
* Another iron storing protein is the '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate.<br /> | * Another iron storing protein is the '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate.<br /> | ||
* '''MrgA''' – another iron storage protein - belongs to the Dps family. | * '''MrgA''' – another iron storage protein - belongs to the Dps family. | ||
== Relevance == | |||
Cavities formed by FR are used for the manufacture of nanoparticles. FR is used as a marker for iron overload disorder. | |||
== Disease == | |||
FR deficiency can lead to anemia. | |||
==3D Structures of Ferritin== | ==3D Structures of Ferritin== | ||
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**[[2chp]] – MrgA – ''Bacillus subtilis''<br /> | **[[2chp]] – MrgA – ''Bacillus subtilis''<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||