1bt6: Difference between revisions
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|PDB= 1bt6 |SIZE=350|CAPTION= <scene name='initialview01'>1bt6</scene>, resolution 2.4Å | |PDB= 1bt6 |SIZE=350|CAPTION= <scene name='initialview01'>1bt6</scene>, resolution 2.4Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene> | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bt6 OCA], [http://www.ebi.ac.uk/pdbsum/1bt6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bt6 RCSB]</span> | |||
}} | }} | ||
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[[Category: Russo-Marie, F.]] | [[Category: Russo-Marie, F.]] | ||
[[Category: Sopkova, J.]] | [[Category: Sopkova, J.]] | ||
[[Category: calcium/phospholipid binding protein]] | [[Category: calcium/phospholipid binding protein]] | ||
[[Category: complex (ligand/annexin)]] | [[Category: complex (ligand/annexin)]] | ||
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[[Category: s100 family]] | [[Category: s100 family]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:07:54 2008'' | ||
Revision as of 19:07, 30 March 2008
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| , resolution 2.4Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS
OverviewOverview
The aggregation and membrane fusion properties of annexin II are modulated by the association with a regulatory light chain called p11.p11 is a member of the S100 EF-hand protein family, which is unique in having lost its calcium-binding properties. We report the first structure of a complex between p11 and its cognate peptide, the N-terminus of annexin II, as well as that of p11 alone. The basic unit for p11 is a tight, non-covalent dimer. In the complex, each annexin II peptide forms hydrophobic interactions with both p11 monomers, thus providing a structural basis for high affinity interactions between an S100 protein and its target sequence. Finally, p11 forms a disulfide-linked tetramer in both types of crystals thus suggesting a model for an oxidized form of other S100 proteins that have been found in the extracellular milieu.
About this StructureAbout this Structure
1BT6 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of a complex of p11 with the annexin II N-terminal peptide., Rety S, Sopkova J, Renouard M, Osterloh D, Gerke V, Tabaries S, Russo-Marie F, Lewit-Bentley A, Nat Struct Biol. 1999 Jan;6(1):89-95. PMID:9886297
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