5hem: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2==
 
<StructureSection load='5hem' size='340' side='right' caption='[[5hem]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
The entry 5hem is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5hem]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HEM FirstGlance]. <br>
Authors: Tallant, C., Lori, C., Pasquo, A., Chiaraluce, R., Consalvi, V., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hem OCA], [http://pdbe.org/5hem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hem RCSB], [http://www.ebi.ac.uk/pdbsum/5hem PDBsum]</span></td></tr>
Description: Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Pasquo, A]]
[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> 
[[Category: Lori, C]]
== References ==
[[Category: Knapp, S]]
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Chiaraluce, R]]
[[Category: Chiaraluce, R]]
[[Category: Bountra, C]]
[[Category: Consalvi, V]]
[[Category: Consalvi, V]]
[[Category: Arrowsmith, C.H]]
[[Category: Delft, F von]]
[[Category: Von Delft, F]]
[[Category: Edwards, A M]]
[[Category: Edwards, A.M]]
[[Category: Knapp, S]]
[[Category: Newman, J.A]]
[[Category: Lori, C]]
[[Category: Newman, J A]]
[[Category: Pasquo, A]]
[[Category: Tallant, C]]
[[Category: Tallant, C]]
[[Category: Post translational modifications recognition]]
[[Category: Transcription]]
[[Category: Transcription regulation]]

Revision as of 20:28, 20 January 2016

Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2

Structural highlights

5hem is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.[1]

References

  1. ↑ LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018

5hem, resolution 1.65Å

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