Ets1: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
Ets1 contains an ETS domain which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices. | Ets1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices. | ||
</StructureSection> | </StructureSection> | ||
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*Ets1 binary complexes | *Ets1 binary complexes | ||
**[[2nny]] – hETS1 + DNA <br /> | **[[2nny]] – hETS1 residues 280-441 + DNA <br /> | ||
**[[3mfk]] – hETS1 + stromelysin promoter DNA <br /> | **[[3mfk]] – hETS1 residues 280-441 + stromelysin promoter DNA <br /> | ||
**[[3ri4]] – hETS1 + TCR α promoter DNA <br /> | **[[3ri4]] – hETS1 residues 280-441 + TCR α promoter DNA <br /> | ||
**[[2stt]], [[2stw]] – hETS1 + DNA - NMR<br /> | **[[2stt]], [[2stw]] – hETS1 ETS domain + DNA - NMR<br /> | ||
**[[1k79]], [[1k7a]] – mETS1 ETS domain + DNA containing GGAA - mouse<br /> | **[[1k79]], [[1k7a]] – mETS1 ETS domain + DNA containing GGAA - mouse<br /> | ||
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**[[1mdm]] – mETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA <br /> | **[[1mdm]] – mETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA <br /> | ||
**[[1k78]] – hETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA - NMR<br /> | **[[1k78]] – hETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA - NMR<br /> | ||
**[[4l0y]], [[4l0z]], [[4l18]] – hETS1 + TCR α promoter DNA + RunT-related transcription factor<br /> | **[[4l0y]], [[4l0z]], [[4l18]] – hETS1 residues 296-441 + TCR α promoter DNA + RunT-related transcription factor<br /> | ||
**[[4lg0]] – hETS1 + cadherin promoter DNA + forkhead box protein<br /> | **[[4lg0]] – hETS1 residues 280-441 + cadherin promoter DNA + forkhead box protein<br /> | ||
}} | }} | ||
Revision as of 19:42, 20 January 2016
FunctionEts1 (E26 Transformation-Specific) is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation[1] . DiseaseRelevanceEts1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells. Structural highlightsEts1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices.
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3D Structures of Ets13D Structures of Ets1
Updated on 20-January-2016
ReferencesReferences
- ↑ Dwyer J, Li H, Xu D, Liu JP. Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. Ann N Y Acad Sci. 2007 Oct;1114:36-47. PMID:17986575 doi:http://dx.doi.org/10.1196/annals.1396.022