EPSP synthase: Difference between revisions

No edit summary
No edit summary
Line 10: Line 10:
== Structural insights ==
== Structural insights ==


The enzyme has <scene name='57/570585/Two_domains/2'>two domains</scene>, with the active site found in the interdomain cleft.  There is a substantial structural change upon substrate binding, resulting in a <scene name='57/570585/Closed_formation/2'>closed formation</scene>. '''Glyphosate''' (also known as '''Roundup''') occupies the binding site of the second substrate, phosphoenol pyruvate <ref>PMID:11171958</ref>.   
The enzyme has <scene name='57/570585/Two_domains/2'>two domains</scene>, with the active site found in the interdomain cleft.  There is a substantial structural change upon substrate binding, resulting in a <scene name='57/570585/Closed_formation/2'>closed formation</scene>. <scene name='57/570585/Cv/3'>See animation of this process</scene>. '''Glyphosate''' (also known as '''Roundup''') occupies the binding site of the second substrate, phosphoenol pyruvate <ref>PMID:11171958</ref>.   
</StructureSection>
</StructureSection>


Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Ann Taylor, Michal Harel, Alexander Berchansky, Joel L. Sussman