Epidermal Growth Factor Receptor: Difference between revisions
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[[Epidermal Growth Factor Receptor]] (EGFR or ERBB1) is found on the cell surface and associates to homodimers upon binding of its ligands such as the Epidermal Growth Factor (EGF) to its extracellular domain. The dimerization stimulates autophosphorylation of several tyrosine residues in the intracellular kinase domain which signal downstream transduction cascades. A human '''EGFR-2 (HER-2 or ERBB2)''' is involved in breast [[Cancer|cancer]] and is a major target for breast cancer [[Pharmaceutical Drugs|therapeutics]]. '''ERBB3''' uses neuregulin as a ligand. '''ERBB4''' is a closely related receptor tyrosine kinase. at the right correspond to one representative EGFR, ''i.e.'' crystal structure of unliganded Drosophila Epidermal Growth Factor Receptor ectodomain ([[3i2t]]). | [[Epidermal Growth Factor Receptor]] (EGFR or ERBB1) is found on the cell surface and associates to homodimers upon binding of its ligands such as the Epidermal Growth Factor (EGF) to its extracellular domain. The dimerization stimulates autophosphorylation of several tyrosine residues in the intracellular kinase domain which signal downstream transduction cascades. A human '''EGFR-2 (HER-2 or ERBB2)''' is involved in breast [[Cancer|cancer]] and is a major target for breast cancer [[Pharmaceutical Drugs|therapeutics]]. '''ERBB3''' uses neuregulin as a ligand. '''ERBB4''' is a closely related receptor tyrosine kinase. at the right correspond to one representative EGFR, ''i.e.'' crystal structure of unliganded ''Drosophila'' Epidermal Growth Factor Receptor ectodomain ([[3i2t]]). | ||
==EGFR and Lung Cancer== | ==EGFR and Lung Cancer== | ||