5fg4: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe==
 
<StructureSection load='5fg4' size='340' side='right' caption='[[5fg4]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
The entry 5fg4 is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5fg4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FG4 FirstGlance]. <br>
Authors: Tallant, C., Owen, D.R., Gerstenberger, B.S., Savitsky, P., Chaikuad, A., Fedorov, O., Nunez-Alonso, G., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5XE:4-BROMANYL-~{N}-(6-METHOXY-1,3-DIMETHYL-2-OXIDANYLIDENE-BENZIMIDAZOL-5-YL)-2-METHYL-BENZENESULFONAMIDE'>5XE</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fg4 OCA], [http://pdbe.org/5fg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5fg4 PDBsum]</span></td></tr>
Description: Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Gerstenberger, B.S]]
[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Chaikuad, A]]
[[Category: Chaikuad, A]]
[[Category: Owen, D.R]]
[[Category: Delft, F von]]
[[Category: Nunez-Alonso, G]]
[[Category: Edwards, A M]]
[[Category: Fedorov, O]]
[[Category: Fedorov, O]]
[[Category: Filippakopoulos, P]]
[[Category: Gerstenberger, B S]]
[[Category: Knapp, S]]
[[Category: Muller, S]]
[[Category: Muller, S]]
[[Category: Knapp, S]]
[[Category: Nunez-Alonso, G]]
[[Category: Bountra, C]]
[[Category: Owen, D R]]
[[Category: Arrowsmith, C.H]]
[[Category: Savitsky, P]]
[[Category: Von Delft, F]]
[[Category: Filippakopoulos, P]]
[[Category: Edwards, A.M]]
[[Category: Tallant, C]]
[[Category: Tallant, C]]
[[Category: Savitsky, P]]
[[Category: Moz-morf complex]]
[[Category: Peregrin]]
[[Category: Transcription]]

Revision as of 23:37, 13 January 2016

Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probeCrystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe

Structural highlights

5fg4 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.[1] [2]

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Ullah M, Pelletier N, Xiao L, Zhao SP, Wang K, Degerny C, Tahmasebi S, Cayrou C, Doyon Y, Goh SL, Champagne N, Cote J, Yang XJ. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol. 2008 Nov;28(22):6828-43. doi: 10.1128/MCB.01297-08. Epub 2008 Sep , 15. PMID:18794358 doi:10.1128/MCB.01297-08

5fg4, resolution 1.65Å

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OCA
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