5fe5: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of human PCAF bromodomain in complex with fragment MB093 (fragment 7)==
 
<StructureSection load='5fe5' size='340' side='right' caption='[[5fe5]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
The entry 5fe5 is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5fe5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FE5 FirstGlance]. <br>
Authors: Chaikuad, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Knapp, S., Structural Genomics Consortium (SGC)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2QC:1-[4-(1,2,3-THIADIAZOL-4-YL)PHENYL]METHANAMINE'>2QC</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
 
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
Description: Crystal structure of human PCAF bromodomain in complex with fragment MB093 (FR7)
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fe5 OCA], [http://pdbe.org/5fe5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fe5 RCSB], [http://www.ebi.ac.uk/pdbsum/5fe5 PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KAT2B_HUMAN KAT2B_HUMAN]] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:8684459</ref> <ref>PMID:9707565</ref> <ref>PMID:10675335</ref> <ref>PMID:23932781</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Histone acetyltransferase]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Chaikuad, A]]
[[Category: Chaikuad, A]]
[[Category: Delft, F von]]
[[Category: Edwards, A M]]
[[Category: Knapp, S]]
[[Category: Knapp, S]]
[[Category: Bountra, C]]
[[Category: Structural genomic]]
[[Category: Arrowsmith, C.H]]
[[Category: Acetylation]]
[[Category: Von Delft, F]]
[[Category: Acetyllysine]]
[[Category: Edwards, A.M]]
[[Category: Bromodomain]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Epigenetic]]
[[Category: Histone]]
[[Category: Histone acetyltransferase kat2b]]
[[Category: Signaling protein]]

Revision as of 23:36, 13 January 2016

Crystal structure of human PCAF bromodomain in complex with fragment MB093 (fragment 7)Crystal structure of human PCAF bromodomain in complex with fragment MB093 (fragment 7)

Structural highlights

5fe5 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:Histone acetyltransferase, with EC number 2.3.1.48
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[KAT2B_HUMAN] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.[1] [2] [3] [4]

References

  1. ↑ Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature. 1996 Jul 25;382(6589):319-24. PMID:8684459 doi:10.1038/382319a0
  2. ↑ Zhang W, Bieker JJ. Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9855-60. PMID:9707565
  3. ↑ Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. Regulation of E2F1 activity by acetylation. EMBO J. 2000 Feb 15;19(4):662-71. PMID:10675335 doi:10.1093/emboj/19.4.662
  4. ↑ Lin R, Tao R, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013 Aug 22;51(4):506-18. doi: 10.1016/j.molcel.2013.07.002. Epub 2013 , Aug 8. PMID:23932781 doi:http://dx.doi.org/10.1016/j.molcel.2013.07.002

5fe5, resolution 2.12Å

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