5ctl: Difference between revisions

Revision as of 23:30, 13 January 2016

Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligandCrystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand

Structural highlights

5ctl is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	5cp5, 5cpe, 5coi, 5cqt, 5crm, 5crz, 5cs8
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.^[1] ^[2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

References

↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

[1] French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779

[2] French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
+<StructureSection load='5ctl' size='340' side='right' caption='[[5ctl]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
-The entry 5ctl is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ctl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CTL FirstGlance]. <br>
-Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB9:N-(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)BENZENESULFONAMIDE'>EB9</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cp5|5cp5]], [[5cpe|5cpe]], [[5coi|5coi]], [[5cqt|5cqt]], [[5crm|5crm]], [[5crz|5crz]], [[5cs8|5cs8]]</td></tr>
-Description: Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ctl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctl OCA], [http://pdbe.org/5ctl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ctl RCSB], [http://www.ebi.ac.uk/pdbsum/5ctl PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Liu, Z]]
+[[Category: Song, M]]
 [[Category: Xu, Y]]
+[[Category: Xue, X]]
 [[Category: Zhang, Y]]
-[[Category: Xue, X]]
+[[Category: Brd4]]
-[[Category: Liu, Z]]
+[[Category: Bromodomain]]
-[[Category: Song, M]]
+[[Category: Dna binding protein-dna binding protein inhibitor complex]]
+[[Category: Four alpha helice]]
+[[Category: Inhibitor complex]]

5ctl: Difference between revisions

Revision as of 23:30, 13 January 2016

Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligandCrystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand

Structural highlights

Disease

Function

References

Contents

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5ctl: Difference between revisions

Revision as of 23:30, 13 January 2016

Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligandCrystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand

Structural highlights

Disease

Function

References

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