1bk5: Difference between revisions
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|PDB= 1bk5 |SIZE=350|CAPTION= <scene name='initialview01'>1bk5</scene>, resolution 2.2Å | |PDB= 1bk5 |SIZE=350|CAPTION= <scene name='initialview01'>1bk5</scene>, resolution 2.2Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=CO:COBALT (II) ION'>CO</scene> | |LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= SRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | |GENE= SRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bk5 OCA], [http://www.ebi.ac.uk/pdbsum/1bk5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bk5 RCSB]</span> | |||
}} | }} | ||
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[[Category: Leighton, L.]] | [[Category: Leighton, L.]] | ||
[[Category: Uy, M.]] | [[Category: Uy, M.]] | ||
[[Category: armadillo repeat containing protein]] | [[Category: armadillo repeat containing protein]] | ||
[[Category: nls nuclear import]] | [[Category: nls nuclear import]] | ||
[[Category: protein transport]] | [[Category: protein transport]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:02:38 2008'' | ||
Revision as of 19:02, 30 March 2008
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| , resolution 2.2Å | |||||||
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| Ligands: | |||||||
| Gene: | SRP1 (Saccharomyces cerevisiae) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
KARYOPHERIN ALPHA FROM SACCHAROMYCES CEREVISIAE
OverviewOverview
Selective nuclear import is mediated by nuclear localization signals (NLSs) and cognate transport factors known as karyopherins or importins. Karyopherin alpha recognizes "classical" monopartite and bipartite NLSs. We report the crystal structure of a 50 kDa fragment of the 60 kDa yeast karyopherin alpha, in the absence and presence of a monopartite NLS peptide at 2.2 A and 2.8 A resolution, respectively. The structure shows a tandem array of ten armadillo repeats, organized in a right-handed superhelix of helices. Binding of the NLS peptide occurs at two sites within a helical surface groove that is lined by conserved residues. The structure reveals the determinants of NLS specificity and suggests a model for the recognition of bipartite NLSs.
About this StructureAbout this Structure
1BK5 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
ReferenceReference
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha., Conti E, Uy M, Leighton L, Blobel G, Kuriyan J, Cell. 1998 Jul 24;94(2):193-204. PMID:9695948
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