1biw: Difference between revisions
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|PDB= 1biw |SIZE=350|CAPTION= <scene name='initialview01'>1biw</scene>, resolution 2.5Å | |PDB= 1biw |SIZE=350|CAPTION= <scene name='initialview01'>1biw</scene>, resolution 2.5Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=S80:N1-HYDROXY-2-(3-HYDROXY-PROPYL)-3-ISOBUTYL-N4-[1-(2-METHOXY-ETHYL)-2-OXO-AZEPAN-3-YL]-SUCCINAMIDE'>S80</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] </span> | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1biw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1biw OCA], [http://www.ebi.ac.uk/pdbsum/1biw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1biw RCSB]</span> | |||
}} | }} | ||
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==Overview== | ==Overview== | ||
A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety. | A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Taiwo, Y O.]] | [[Category: Taiwo, Y O.]] | ||
[[Category: Wahl, C T.]] | [[Category: Wahl, C T.]] | ||
[[Category: matrix metalloprotease]] | [[Category: matrix metalloprotease]] | ||
[[Category: osteoarthritis]] | [[Category: osteoarthritis]] | ||
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[[Category: structure-based drug design]] | [[Category: structure-based drug design]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:01:57 2008'' | ||