Bungarotoxin: Difference between revisions

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<StructureSection load='1hc9' size='450' side='right' scene='42/423360/Cv/2' caption='α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code 1hc9)'>
<StructureSection load='1hc9' size='450' side='right' scene='42/423360/Cv/2' caption='α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code [[1hc9]])'>
[[Bungarotoxin|Bungarotoxins]]. α-Bungarotoxin (α-BGT),  β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.<br />
[[Bungarotoxin|Bungarotoxins]]. α-Bungarotoxin (α-BGT),  β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.<br />
*  '''α-BGT'''  binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in [[Alpha-bungarotoxin]].<br />
*  '''α-BGT'''  binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in [[Alpha-bungarotoxin]].<br />
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For toxins in Proteopedia see [[Toxins]].
For toxins in Proteopedia see [[Toxins]].


<scene name='42/423360/Cv/3'>Iod coordination site</scene> in α-Bungarotoxin (PDB code 1hc9).
<scene name='42/423360/Cv/3'>Iod coordination site</scene> in α-Bungarotoxin (PDB code [[1hc9]]).<ref>PMID:11683996</ref>
</StructureSection>
</StructureSection>
== 3D Structures of Bungarotoxin ==  
== 3D Structures of Bungarotoxin ==  
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}}
}}
== References ==
== References ==
<references/>


[[Alpha-bungarotoxin]]
[[Alpha-bungarotoxin]]
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 17:33, 13 January 2016

Bungarotoxins. α-Bungarotoxin (α-BGT), β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.

  • α-BGT binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in Alpha-bungarotoxin.
  • β-BGT binds to the presynaptic terminal causing release of acetylcholine.
  • γ-BGT inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor.
  • κ-BGT binds weakly to the nicotinic acetylcholine receptor.

For toxins in Proteopedia see Toxins.

in α-Bungarotoxin (PDB code 1hc9).[1]

α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code 1hc9)

Drag the structure with the mouse to rotate

3D Structures of Bungarotoxin3D Structures of Bungarotoxin

Updated on 13-January-2016

ReferencesReferences

  1. Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996

Alpha-bungarotoxin

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel