PLC beta 3 Gq: Difference between revisions
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==Unique bidirectional interactions of Phospholipase C beta 3 with G alpha Q== | ==Unique bidirectional interactions of Phospholipase C beta 3 with G alpha Q== | ||
<StructureSection load='3ohm' size='340' side='right' caption=' | <StructureSection load='3ohm' size='340' side='right' caption='Human phospholipase C β 3 (green) complex with guanine nucleotide-binding protein subunit α (grey) (PDB code [[3ohm]]) ' scene=''> | ||
== Introduction == | == Introduction == | ||
Phospholipase C beta 3 ([http://en.wikipedia.org/wiki/PLCB3 PLC-β3]) catalyzes the hydrolysis of phosphatidylinositol 4,5 bisphosphate ([http://en.wikipedia.org/wiki/Phosphatidylinositol_4,5-bisphosphate PIP2]) to the second messengers inositol 1,4,5-trisphosphate ([http://en.wikipedia.org/wiki/Inositol_trisphosphate IP3]) and diacylglycerol ([http://en.wikipedia.org/wiki/Diglyceride DAG]) in an essential step for many physiological cascades. When the receptor stimulated by ligand of some kind, it increases exchange of guanosine diphosphate (GDP) to guanosine triphosphate (GTP) on [http://en.wikipedia.org/wiki/Gq_alpha_subunit Gαq]. GTP-bound Gαq activates PLC-β3, and PLC-β3 increases up to three orders of magnitude the rate of hydrolysis of GTP by its activating G protein. This is a unique mechanism in which PLC-β3 enzyme has the ability to terminate the Gαq protein signal, in addition to being activated by it.<ref>PMID:20966218</ref> <ref>PMID:23880553</ref> | '''Phospholipase C beta 3''' ([http://en.wikipedia.org/wiki/PLCB3 PLC-β3]) catalyzes the hydrolysis of phosphatidylinositol 4,5 bisphosphate ([http://en.wikipedia.org/wiki/Phosphatidylinositol_4,5-bisphosphate PIP2]) to the second messengers inositol 1,4,5-trisphosphate ([http://en.wikipedia.org/wiki/Inositol_trisphosphate IP3]) and diacylglycerol ([http://en.wikipedia.org/wiki/Diglyceride DAG]) in an essential step for many physiological cascades. When the receptor stimulated by ligand of some kind, it increases exchange of guanosine diphosphate (GDP) to guanosine triphosphate (GTP) on [http://en.wikipedia.org/wiki/Gq_alpha_subunit Gαq]. GTP-bound Gαq activates PLC-β3, and PLC-β3 increases up to three orders of magnitude the rate of hydrolysis of GTP by its activating G protein. This is a unique mechanism in which PLC-β3 enzyme has the ability to terminate the Gαq protein signal, in addition to being activated by it.<ref>PMID:20966218</ref> <ref>PMID:23880553</ref> | ||
== Structural highlights == | == Structural highlights == | ||
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Shir Navot, Michal Harel, Joel L. SussmanCitation: Navot S, Harel M, 2016, "PLC beta 3 Gq",