Nucleoprotein

Nucleoproteins (NP) are associated with DNA or RNA. NPs which contain RNA are called ribonucleoproteins (RNPs). The NP RNA-recognition motif is named RRM. The small nuclear ribonucleoproteins (snRNPs) are RNA-protein complexes which form part of the spliceosome. The heterogenous nuclear ribonucleoproteins (hnRNP) are RNA-protein complexes which associates with the splicing apparatus and prevent the folding of pre-mRNA.
For details on heterogenous nuclear ribonucleoproteins see HnRNP A1.
For homology model and multiple sequence alignment see User:Michael Strong/H1N1/NP and User:Michael Strong/H1N1/NP/MSA.

3D Structures of Nucleoprotein3D Structures of Nucleoprotein

Updated on 06-January-2016

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• Nucleoprotein
  • 3ouo, 3ov9 – NP – Rift valley fever virus
    
  • 3q7b, 3q7c – LvNP exonuclease domain – Lassa virus
    
  • 3mwp, 3mwt, 3r3l – LvNP
    
  • 3pto - VvNP – Vesicular stomatitis Indiana virus
    
  • 2qvj – VvNP (mutant)
    
  • 2k48 – NP N terminal – Andes virus - NMR
    
  • 1ssk - ScvNP N terminal – SARS coronavirus – NMR
    
  • 4j3k – ScvNP N terminal
    
  • 2gib – ScvNP dimerization domain
    
  • 2jw8 - ScvNP dimerization domain – NMR
    
  • 2ofz, 2og3 - ScvNP RNA-binding domain
    
  • 3hd4 – NP N terminal – Murine hepatitis virus
    
  • 2wfs, 2ymn – IvNP – Cryo EM – Influenza virus
    
  • 4dys, 4iry – IvNP
    
  • 3zdp, 4dyt – IvNP (mutant)
    
  • 2q06, 2iqh, 3tj0 – IvNP
    
  • 2i8b – EvNP C terminal – Ebola virus – NMR
    
  • 3v7o, 4qaz, 4qb0 - EvNP C terminal
    
  • 1yvr – XlNP Ro – Xenopus laevis
    
  • 1wwf – MvNP P10 – Moloney murine leukemia virus – NMR
    
  • 2c86, 2gec – BvNP N terminal – Avian infectious bronchitis virus
    
  • 2ca1, 2ge7, 2ge8 – BvNP dimerization domain
    
  • 2btl, 2bxx – BvNP RRM (mutant)
    
  • 1n93, 1pp1 – NP P40 – Borna disease virus
    
  • 4aqf, 4aqg – NP N – Crimean-Congo hemorrhagic fever virus
    
  • 4fi5 – NP N terminal – Hantaan virus
    
  • 4bgp – LcvNP – La crosse virus
    
  • 4gve – NP C terminal – Tacaribe virus
    
  • 4idu, 4idx – SvNP – Schmallenberg virus
    
  • 4k7e – NP C terminal – Junin virus
    
  • 4o6h – NP C terminal – Lymphocytic choriomeningitis virus
    
• Nucleoprotein binary complex
  • 3mx2, 3mx5 – LvNP + nucleotide
    
  • 3t5n, 3t5q, 4fvu, 4g9z, 4gv3, 4gv6, 4gv9 – LvNP + RNA
    
  • 3ptx, 3pu0, 3pu1, 3pu4, 2gic – VvNP + RNA
    
  • 2wyy – VvNP + poly U – Cryo EM
    
  • 3hhw, 3pmk – VvNP + phosphoprotein
    
  • 3hhz - VvNP + phosphoprotein + RNA
    
  • 4co6 - NP + phosphoprotein – Nipah virus
    
  • 2wj8, 2yhm, 4bkk – NP + RNA – Human respiratory syncytial virus
    
  • 2i91, 1yvp – XlNP Ro + RNA
    
  • 2gtt – NP + RNA – Rabies virus
    
  • 1wwg, 1wwd, 1wwe, 1u6p - MvNP P10 + RNA – NMR
    
  • 3ro5, 4dya, 4dyb, 4dyn, 4dyp, 3tg6 – IvNP + ligand
    
  • 4bbl – IvNP + RNA – Cryo EM
    
  • 3zla – BvNP + RNA – Bunyamwera virus
    
  • 4ijs – BvNP (mutant) + RNA
    
  • 4bhh – LcvNP + poly-U
    
  • 4jng – SvNP + RNA
    
  • 4j1g, 4j1j – NP + RNA – Leanye virus
    
  • 4kxj – ScvNP N terminal + PJ34
    
  • 4li4, 4lm7, 4lm9, 4lmc – ScvNP N terminal + nucleotide
    
  • 4lmt – ScvNP N terminal + quinoline derivative
    
  • 4ypi - EvNP + peptide – Cryo EM
    
• Ribonucleoprotein
  • 2lbw – yRNP subunit 2 residues 36-156 (mutant) – yeast – NMR
    
  • 2lbx - yRNP subunit 2 residues 36-156 – NMR
    
  • 4h5l, 4csg – TvRNP – Toscana virus
    
  • 4csf – TvRNP + RNA
    
  • 4uft – RNP + RNA – Measles virus
    
• Small nuclear ribonucleoprotein
  • 2a3j, 1fht - h-snRNP U1 A RRM – human - NMR
    
  • 2u1a - h-snRNP U1 A RRM (mutant) – NMR
    
  • 1dz5 - h-snRNP U1 A (mutant) – NMR
    
  • 1oia - h-snRNP U1 A RRM
    
  • 2l5i, 2l5j - h-snRNP U1 70kDa residues 131-151 – NMR
    
  • 2vy4, 2vy5 - h-snRNP U11/U12 – NMR
    
  • 2cqj - h-snRNP U3 S4 domain – NMR
    
  • 1x4q - h-snRNP U4/U6 PWI domain - NMR
    
  • 2vrd - h-snRNP U1 C zinc finger domain - NMR
    
  • 1b34 - h-snRNP D1 + h-snRNP D2
    
  • 1d3b - h-snRNP SM D3 SM motif + h-snRNP-associated protein
    
  • 1khm - h-snRNP K C terminal (mutant) – NMR
    
  • 2k3k – Dm-snRNP U1 A RRM1 – Drosophila melanogaster – NMR
    
  • 2aym - Dm-snRNP U1 A
    
  • 2b0g - Dm-snRNP U1 A RBD2 – NMR
    
  • 1n9r, 1n9s – y-snRNP F
• Small nuclear ribonucleoprotein binary complex
  • 3plu, 3plv – y-snRNP HINDI domain + ubiquitin-like modifier HUB1
    
  • 2y9a, 2y9b, 2y9c, 2y9d – h-snRNP U4 core domain
    
  • 3p49 - h-snRNP A RRM + glycine riboswitch RNA
    
  • 3iwn - h-snRNP U1 A RRM (mutant) + riboswitch RNA
    
  • 3pgw, 3mum, 3mur, 3mut, 3muv, 3egz - h-snRNP U1 A + DNA riboswitch
    
  • 3mxh, 3irw - h-snRNP U1 A (mutant) + DNA riboswitch
    
  • 3k0j, 1drz, 1m5k, 1m5o, 1m5p, 1m5v, 1u6b, 3ucu, 3ucz, 3ud3, 3ud4 - h-snRNP U1 A (mutant) + RNA
    
  • 3bo2, 3bo3, 3bo4 - h-snRNP U1 A RRM + RNA
    
  • 1sj3, 1sj4, 1sjf, 1vbx, 1vby, 1vbz, 1vc0, 1vc5, 1vc6, 1vc7 - h-snRNP U1 A (mutant) + Hepatitis ribozyme
    
  • 3r1h, 3r1l - h-snRNP U1 A (mutant) + ribozyme
    
  • 1aud - h-snRNP U1 A (mutant) + RNA - NMR
    
  • 3iin - h-snRNP U1 A (mutant) + group I intron + DNA
    
  • 4c4w - h-snRNP A RRM 1 + TSKT K-turn motif + ribosomal protein L7AE
    
  • 3b02, 3b03, 3b04 - h-snRNP U1 A RRM1 + group I intron + RNA
    
  • 1zzn - h-snRNP U1 A RRM1 (mutant) + group I intron + RNA
    
  • 3l3c, 3g8s, 3g8t, 3g96, 3g9c, 2nz4 - h-snRNP U1 A (mutant) + GLMS ribozyme + RNA
    
  • 3hhn - h-snRNP U1 A (mutant) + class I ligase ribozyme
    
  • 2oih, 2oj3 - h-snRNP U1 A + HDV ribozyme
    
  • 3cul, 3cun - h-snRNP U1 A (mutant) + aminoacyl-tRNA synthetase ribozyme
    
  • 3cw1 - h-snRNP U1 in spliceosome
    
  • 2ozb, 3siu, 3siv - h-snRNP U4/U6 + NHP2-like protein + RNA
    
  • 3s6n, 1vu2, 1vu3, 4f77, 4f7u - h-snRNP 8S assembly
    
  • 4m77, 4m78, 4m7a, 4m7d - h-snRNP LSM8 assembly
    
  • 2bn5 - Dm-snRNP U1 70kDa + PSI B box – NMR
    
• Heterogenous nuclear ribonucleoprotein
  • 3s01 – m-hnRNP L RRM3 domain – mouse
    
  • 3tyt - m-hnRNP L
    
  • 2e5i - m-hnRNP L RRM – NMR
    
  • 2db1 - m-hnRNP F RRM – NMR
    
  • 1ha1, 1l3k, 1up1 - h-hnRNP A1 RRM
    
  • 2lyv - h-hnRNP A1 RRM 1-2 – NMR
    
  • 2up1 - h-hnRNP A1 RRM 1-2 + DNA
    
  • 3s7r - h-hnRNP A/B
    
  • 1x4b - h-hnRNP A2/B1 RRM – NMR
    
  • 1txp - h-hnRNP C oligomerization domain – NMR
    
  • 1wf2 - h-hnRNP C1/C2 RRM – NMR
    
  • 1hd0, 1hd1, 1iqt - h-hnRNP D0 RRM – NMR
    
  • 2hgl, 2hgm, 2hgn - h-hnRNP F QRRM – NMR
    
  • 1wg5, 1wez, 2lxu - h-hnRNP H RRM – NMR
    
  • 2ad9, 2adb, 2adc - h-hnRNP I – NMR
    
  • 1zzk - h-hnRNP K KH domain
    
  • 3r27, 3t08 - h-hnRNP L RRM
    
  • 2do0, 2dh9, 2dgv - h-hnRNP M RRM – NMR
    
  • 2dgu - h-hnRNP Q RRM – NMR
    
  • 2dk2 - h-hnRNP R RRM – NMR
    
• Heterogenous nuclear ribonucleoprotein binary complex
  • 2kfy, 2kg0, 2kg1 - h-hnRNP F QRRM + DNA – NMR
    
  • 2z5n, 2z5o, 2ot8 - h-hnRNP D0 CTD + transportin-1
    
  • 1u1k, 1u1l, 1u1m, 1u1n, 1u1o, 1u1p, 1u1q, 1u1r, 1up1 - h-hnRNP A1 RRM + DNA
    
  • 1pgz, 1po6 - h-hnRNP A1 + DNA + inhibitor
    
  • 1wtb, 1x0f - h-hnRNP D0 RRM + DNA – NMR
    
  • 1zzi, 1zzj - h-hnRNP K KH domain + DNA
    
  • 1j5k - h-hnRNP K KH domain + DNA – NMR