Cyclin-dependent kinase regulatory subunit: Difference between revisions
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<StructureSection load='1dks' size='340' side='right' caption='Human CKS-1 complex with phosphate (PDB code [[1dks]])' scene=''> | <StructureSection load='1dks' size='340' side='right' caption='Human CKS-1 complex with phosphate (PDB code [[1dks]])' scene=''> | ||
'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. CKS1 is essential for CDK5 functioning in neuronal | '''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. CKS1 is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8471379</ref> | ||
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== Structural highlights == | == Structural highlights == | ||
CKS exists as hexamer of homodimers and can bind six kinase molecules. | |||
</StructureSection> | </StructureSection> | ||