Deoxyuridine 5'-triphosphate nucleotidohydrolase: Difference between revisions
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<StructureSection load='1w2y' size='350' side='right' caption='dUTPase | <StructureSection load='1w2y' size='350' side='right' caption='dUTPase complex with dUTP analog (stick model) and Mg+2 ions (green) (PDB entry [[1w2y]])' scene=''> | ||
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DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis. | DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis. | ||
== Structural highlights == | |||
The active site contains Mg<sup>+2</sup> ions which are essensial for DUTP activity. The Mg<sup>+2</sup> ions are hexacordinated to acidic residues and water molecules.<ref>PMID:15364583</ref> | |||
</StructureSection> | </StructureSection> | ||
==3D structures of dUTPase== | ==3D structures of dUTPase== | ||