Deoxyuridine 5'-triphosphate nucleotidohydrolase: Difference between revisions
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<StructureSection load='1smc' size='350' side='right' caption='dUTPase trimer complex with dUTP (stick model), nitrate and Tris (PDB entry [[1smc]])' scene=''> | |||
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'''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. | == Function == | ||
'''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. | |||
Prokaryotic DUTP contains metal ion. <ref>PMID:11742345</ref> | |||
== Relevance == | |||
DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis. | |||
</StructureSection> | |||
==3D structures of dUTPase== | ==3D structures of dUTPase== | ||
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**[[4aoo]], [[4apz]], [[4aoz]] - BsDUTP + Mg + PPi + uridine<br /> | **[[4aoo]], [[4apz]], [[4aoz]] - BsDUTP + Mg + PPi + uridine<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||