5f5a: Difference between revisions

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'''Unreleased structure'''
==Crystal Structure of human JMJD2D complexed with KDOAM16==
 
<StructureSection load='5f5a' size='340' side='right' caption='[[5f5a]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
The entry 5f5a is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5f5a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F5A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F5A FirstGlance]. <br>
Authors: Krojer, T., Vollmar, M., Crawley, L., Bradley, A.R., Szykowska, A., Ruda, G.F., Yang, H., Burgess-Brown, N., Brennan, P., Burley, S.K., Bountra, C., Arrowsmith, C.H., Edwards, A., Oppermann, U., von Delft, F., Structural Genomics Consortium (SGC)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5V0:2-[(FURAN-2-YLMETHYLAMINO)METHYL]PYRIDINE-4-CARBOXYLIC+ACID'>5V0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f5a OCA], [http://pdbe.org/5f5a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f5a RCSB], [http://www.ebi.ac.uk/pdbsum/5f5a PDBsum]</span></td></tr>
Description: Crystal Structure of human JMJD2D complexed with KDOAM16
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Ruda, G.F]]
[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bradley, A R]]
[[Category: Brennan, P]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown, N]]
[[Category: Yang, H]]
[[Category: Burley, S K]]
[[Category: Crawley, L]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
[[Category: Bountra, C]]
[[Category: Vollmar, M]]
[[Category: Burley, S.K]]
[[Category: Arrowsmith, C.H]]
[[Category: Oppermann, U]]
[[Category: Oppermann, U]]
[[Category: Ruda, G F]]
[[Category: Structural genomic]]
[[Category: Szykowska, A]]
[[Category: Szykowska, A]]
[[Category: Crawley, L]]
[[Category: Vollmar, M]]
[[Category: Von Delft, F]]
[[Category: Yang, H]]
[[Category: Bradley, A.R]]
[[Category: Demethylase]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Double-stranded beta helix]]
[[Category: Edwards, A]]
[[Category: Oxidoreductase]]
[[Category: Brennan, P]]
[[Category: Oxygenase]]
[[Category: Sgc]]

Revision as of 16:59, 16 December 2015

Crystal Structure of human JMJD2D complexed with KDOAM16Crystal Structure of human JMJD2D complexed with KDOAM16

Structural highlights

5f5a is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[KDM4D_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.[1]

References

  1. ↑ Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell. 2006 May 5;125(3):467-81. Epub 2006 Apr 6. PMID:16603238 doi:10.1016/j.cell.2006.03.028

5f5a, resolution 1.41Å

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