4y59: Difference between revisions
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''' | ==Crystal structure of ALiS1-Streptavidin complex== | ||
<StructureSection load='4y59' size='340' side='right' caption='[[4y59]], [[Resolution|resolution]] 1.22Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4y59]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y59 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T21:2-[3-(TRIFLUOROMETHYL)PHENYL]FURO[3,2-C]PYRIDIN-4(5H)-ONE'>T21</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4y5d|4y5d]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y59 OCA], [http://pdbe.org/4y59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y59 RCSB], [http://www.ebi.ac.uk/pdbsum/4y59 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV]] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin). | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Artificial ligands of streptavidin (ALiS) with association constants of approximately 10(6) M(-1) were discovered by high-throughput screening of our chemical library, and their binding characteristics, including X-ray crystal structure of the streptavidin complex, were determined. Unlike biotin and its derivatives, ALiS exhibits fast dissociation kinetics and excellent cell permeability. The streptavidin-ALiS system provides a novel, practical compound-dependent methodology for repeated reversible cycling of protein localization between intracellular organella. | |||
Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport.,Terai T, Kohno M, Boncompain G, Sugiyama S, Saito N, Fujikake R, Ueno T, Komatsu T, Hanaoka K, Okabe T, Urano Y, Perez F, Nagano T J Am Chem Soc. 2015 Aug 26;137(33):10464-7. doi: 10.1021/jacs.5b05672. Epub 2015 , Aug 11. PMID:26261872<ref>PMID:26261872</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4y59" style="background-color:#fffaf0;"></div> | |||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ishida, H]] | |||
[[Category: Kohno, M]] | |||
[[Category: Nagano, T]] | [[Category: Nagano, T]] | ||
[[Category: Sugiyama, S]] | [[Category: Sugiyama, S]] | ||
[[Category: | [[Category: Terai, T]] | ||
[[Category: Biotin-binding protein]] | |||
[[Category: Inhibitor]] | |||
Revision as of 10:44, 16 December 2015
Crystal structure of ALiS1-Streptavidin complexCrystal structure of ALiS1-Streptavidin complex
Structural highlights
Function[SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin). Publication Abstract from PubMedArtificial ligands of streptavidin (ALiS) with association constants of approximately 10(6) M(-1) were discovered by high-throughput screening of our chemical library, and their binding characteristics, including X-ray crystal structure of the streptavidin complex, were determined. Unlike biotin and its derivatives, ALiS exhibits fast dissociation kinetics and excellent cell permeability. The streptavidin-ALiS system provides a novel, practical compound-dependent methodology for repeated reversible cycling of protein localization between intracellular organella. Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport.,Terai T, Kohno M, Boncompain G, Sugiyama S, Saito N, Fujikake R, Ueno T, Komatsu T, Hanaoka K, Okabe T, Urano Y, Perez F, Nagano T J Am Chem Soc. 2015 Aug 26;137(33):10464-7. doi: 10.1021/jacs.5b05672. Epub 2015 , Aug 11. PMID:26261872[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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