1at3: Difference between revisions
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|PDB= 1at3 |SIZE=350|CAPTION= <scene name='initialview01'>1at3</scene>, resolution 2.5Å | |PDB= 1at3 |SIZE=350|CAPTION= <scene name='initialview01'>1at3</scene>, resolution 2.5Å | ||
|SITE= <scene name='pdbsite=ACT:Novel+Active+Site+Triad+SER+129,+HIS+61+And+HIS+148'>ACT</scene> | |SITE= <scene name='pdbsite=ACT:Novel+Active+Site+Triad+SER+129,+HIS+61+And+HIS+148'>ACT</scene> | ||
|LIGAND= <scene name='pdbligand=DFP:DIISOPROPYL PHOSPHONATE'>DFP</scene> | |LIGAND= <scene name='pdbligand=DFP:DIISOPROPYL+PHOSPHONATE'>DFP</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1at3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1at3 OCA], [http://www.ebi.ac.uk/pdbsum/1at3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1at3 RCSB]</span> | |||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
1AT3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | 1AT3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_2 Human herpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AT3 OCA]. | ||
==Reference== | ==Reference== | ||
Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex., Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS, Biochemistry. 1997 Nov 18;36(46):14023-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9369473 9369473] | Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex., Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS, Biochemistry. 1997 Nov 18;36(46):14023-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9369473 9369473] | ||
[[Category: Human herpesvirus | [[Category: Human herpesvirus 2]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Abdel-Meguid, S S.]] | [[Category: Abdel-Meguid, S S.]] | ||
| Line 26: | Line 29: | ||
[[Category: Qiu, X.]] | [[Category: Qiu, X.]] | ||
[[Category: Smith, W W.]] | [[Category: Smith, W W.]] | ||
[[Category: hsv2 protease]] | [[Category: hsv2 protease]] | ||
[[Category: serine protease]] | [[Category: serine protease]] | ||
[[Category: viral protease]] | [[Category: viral protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:46:57 2008'' | ||
Revision as of 18:47, 30 March 2008
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| , resolution 2.5Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HERPES SIMPLEX VIRUS TYPE II PROTEASE
OverviewOverview
Human herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are responsible for herpes labialis (cold sores) and genital herpes, respectively. They encode a serine protease that is required for viral replication, and represent a viable target for therapeutic intervention. Here, we report the crystal structures of HSV-1 and HSV-2 proteases, the latter in the presence and absence of the covalently bound transition state analog inhibitor diisopropyl phosphate (DIP). The HSV-1 and HSV-2 protease structures show a fold that is neither like chymotrypsin nor like subtilisin, and has been seen only in the recently determined cytomegalovirus (CMV) and varicella-zoster virus (VZV) protease structures. HSV-1 and HSV-2 proteases share high sequence homology and have almost identical three-dimensional structures. However, structural differences are observed with the less homologous CMV protease, offering a structural basis for herpes virus protease ligand specificity. The bound inhibitor identifies the oxyanion hole of these enzymes and defines the active site cavity.
About this StructureAbout this Structure
1AT3 is a Single protein structure of sequence from Human herpesvirus 2. Full crystallographic information is available from OCA.
ReferenceReference
Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex., Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS, Biochemistry. 1997 Nov 18;36(46):14023-9. PMID:9369473
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