Core-binding factor: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='1h9d' size='340' side='right' caption='Human CBFα runt domain (grey and pink) complex with CBFβ heterodimerization domain (green and yellow) and DNA (PDB code [[1h9d]])' scene=''> | <StructureSection load='1h9d' size='340' side='right' caption='Human CBFα runt domain (grey and pink) complex with CBFβ heterodimerization domain (green and yellow) and DNA (PDB code [[1h9d]])' scene=''> | ||
== Function == | == Function == | ||
'''Core-binding factor''' (CBF) is a heterodimeric transcription factor which is composed of α chain which binds DNA and a regulatory β chain. CBF binds to various enhancers and promoters including murine leukemia virus and polyomavirus enhancer. <ref>PMID:11276260</ref> | |||
== Disease == | == Disease == | ||
| Line 11: | Line 12: | ||
== Structural highlights == | == Structural highlights == | ||
CBF α contains a DNA-binding runt domain (residues 50-177). | |||
</StructureSection> | </StructureSection> | ||