Complement factor: Difference between revisions
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== Function == | == Function == | ||
'''Complement factor H''' (CFH) regulates the complement system which is part of the immune response. CFH protects cells by preventing the activation of the complement system when it is not needed. CFH contains 20 short consensus repeats (sushi domains, i.e., a 5 strand β-sandwich arrangement). | '''Complement factor H''' (CFH) regulates the complement system which is part of the immune response. CFH protects cells by preventing the activation of the complement system when it is not needed. CFH contains 20 short consensus repeats (sushi domains, i.e., a 5 strand β-sandwich arrangement).<ref>PMID:15163532</ref> | ||
== Disease == | == Disease == | ||
CFH mutations are involved in dense deposit disease, age-related macular degeneration, atypical hemolytic-uremic syndrome and the kidney disorder glomerulonephritis. | CFH mutations are involved in dense deposit disease, age-related macular degeneration, atypical hemolytic-uremic syndrome, schizophrenia, stroke and the kidney disorder glomerulonephritis. | ||
== Relevance == | == Relevance == | ||
CFH is recruited by human pathogens resulting in increased virulence. | |||
== Structural highlights == | == Structural highlights == | ||
The sushi domains are ca. 60 amino acid long containing 2 Cys-Cys bonds. | |||
</StructureSection> | </StructureSection> | ||